Here’s a detailed list of the benefits of TUDCA (Tauroursodeoxycholic Acid), based on scientific studies and clinical observations:
1. Neuroprotective Effects
-
Reduces ER stress and mitochondrial dysfunction, both involved in neurodegenerative diseases.
-
Studied for potential in Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease.
-
May help reduce brain inflammation and support cognitive function.
2. Liver Health Support
-
Originally used to treat cholestasis (bile flow issues).
-
Aids in protecting liver cells from damage due to toxins, alcohol, fatty liver, and drugs (e.g., steroids or acetaminophen).
-
May improve liver enzyme levels in people with non-alcoholic fatty liver disease (NAFLD).
3. Mitochondrial & Cellular Health
-
TUDCA improves mitochondrial membrane integrity.
-
Reduces apoptosis (cell death) under stress conditions.
-
Useful for overall cellular resilience and anti-aging support.
4. Improved Insulin Sensitivity
-
Some studies suggest TUDCA can improve insulin signaling and reduce insulin resistance, especially in obese individuals.
-
It may support glucose metabolism and reduce markers of metabolic syndrome.
5. Eye Health
-
Protects retinal ganglion cells and may be helpful in retinal degeneration or glaucoma.
-
Helps reduce oxidative stress and apoptosis in the retina.
6. Bodybuilding & Cycle Support
-
Often used during or after anabolic steroid cycles to protect the liver.
-
Can help counteract hepatotoxicity from oral steroids like superdrol, anadrol, or methylated compounds.
7. Anti-Inflammatory & Cytoprotective
-
Suppresses pro-inflammatory cytokines.
-
Reduces oxidative stress markers in various tissues, including the liver, brain, and eyes.
Possible Side Effects of TUDCA
1. Gastrointestinal Issues
-
Most common side effect
-
Can include:
-
Diarrhea
-
Nausea
-
Bloating or gas
-
Mild stomach cramps
-
2. Fatigue or Headache
-
Reported by a small number of users.
-
Possibly due to liver detox reactions or shifts in metabolism.
3. Interactions with Medications
-
TUDCA may interact with bile-affecting drugs, like:
-
Cholestyramine
-
Clofibrate
-
Cyclosporine
-
-
It can also affect the absorption of fat-soluble vitamins (A, D, E, K) in theory.
4. Changes in Bile Composition
-
Overuse could theoretically lead to:
-
Gallstone issues (though UDCA/TUDCA are also used to dissolve gallstones)
-
Disruption of natural bile acid balance
-
5. Unknown Long-Term Effects
-
Most studies are short to medium term.
-
Long-term safety (>1 year) in healthy users isn’t well documented yet.
Typical Dosage Range
-
General health/liver support:
250–500 mg per day -
Heavy liver stress (e.g., from oral steroids or meds):
500–1,000 mg per day, often split into two doses -
Therapeutic / Clinical doses (under supervision):
Up to 1,500 mg/day, especially in studies on liver disease or insulin resistance
Top-Selling TUDCA: